集成电路用Ti靶材和Cu62Zn38合金背板焊接技术研究

研究了高纯Ti和Cu62Zn38合金在不同的工艺条件下的扩散焊接性能和界面情况。结果表明,热等静压温度为510℃时,加工态Ti板硬度下降明显,与退火态Cu62Zn38接近;退火态Ti板和退火态Cu62Zn38两种材料硬度较为接近,而在温度接近525℃时,退火态Cu62Zn38合金硬度明显高于退火态Ti板。退火态Cu62Zn38合金与退火态高纯Ti经过焊接温度525℃,压力120 MPa,保温4 h的扩散焊接后,平均抗拉强度能达到136 MPa,焊接界面达到冶金结合,满足Ti靶材的使用要求。     

省级示范性特色专业建设思路与目标研究

经过三年建设,环境监测与评价专业将成为完善专业动态调整机制,深化校企合作长效机制,构建"三四三"人才培养模式,优化"工学结合"特色课程体系,打造高水平教学团队,建设"四位一体"实训基地,开发共享型优质教学资源,创新教学管理制度,提升专业服务社会能力,充分发挥专业示范引领作用的省内领先、国内一流的省级示范性特色专业。     

ICP-AES法测定ITiO(铟钛靶材)中铁钙镁锡

建立了电感耦合等离子原子发射光谱法测定ITi O(铟钛靶材)粉末中Fe、Ca、Mg和Sn等杂质元素的分析方法。对溶液酸度、基体干扰、共存元素干扰等进行了试验和讨论,优化了仪器工作参数,方法的精密度(RSD,n=9)为0.41%~2.51%;回收率为99%~103%。适用于ITiO(铟钛靶材)粉末中杂质元素铁、钙、镁和锡量的测定。     

工程管理软件Project 2007在化工装置大修应用

现代石油化工装置大修实施阶级是一项复杂的过程管理,用传统的方法统计人员、机具数量及任务完成情况,从而实行资源有效的调配,实现施工作业过程的管理,已不适用,必须要有高效的辅助手段。微软公司发布Project 2007软件功能强大、实用性、操作性都能满足此方面的要求。本文通过具体案例的分析,探讨利用Project 2007软件在大修实施过程中如何进行人员、机具及任务完成的统计。     

房地产企业责任成本管理研究

分析责任成本管理概念及特点,阐述责任成本管理在房地产企业中的应用流程。结合顺义平各庄项目,介绍责任成本管理的开展情况,为相关地产企业成本管理拓宽思路提供参考。     

Molecular Targeting of the Oncoprotein PLK1 in Pediatric Acute Myeloid Leukemia: RO3280, a Novel PLK1 Inhibitor,Induces Apoptosis in Leukemia Cells

Polo-like kinase 1 (PLK1) is highly expressed in many cancers and therefore a biomarker of transformation and potential target for the development of cancer-specific small molecule drugs. RO3280 was recently identified as a novel PLK1 inhibitor; however its therapeutic effects in leukemia treatment are still unknown. We found that the PLK1 protein was highly expressed in leukemia cell lines as well as 73.3% (11/15) of pediatric acute myeloid leukemia (AML) samples. PLK1 mRNA expression was significantly higher in AML samples compared with control samples (82.95 ± 110.28 vs. 6.36 ± 6.35; p < 0.001). Kaplan-Meier survival analysis revealed that shorter survival time correlated with high tumor PLK1 expression (p = 0.002). The 50% inhibitory concentration (IC₅₀) of RO3280 for acute leukemia cells was between 74 and 797 nM. The IC₅₀ of RO3280 in primary acute lymphocytic leukemia (ALL) and AML cells was between 35.49 and 110.76 nM and 52.80 and 147.50 nM, respectively. RO3280 induced apoptosis and cell cycle disorder in leukemia cells. RO3280 treatment regulated several apoptosis-associated genes. The regulation of DCC, CDKN1A, BTK, and SOCS2 was verified by western blot. These results provide insights into the potential use of RO3280 for AML therapy; however, the underlying mechanisms remain to be determined.     

无人机跟踪地面目标无碰撞航迹规划

针对无人机自动跟踪目标过程中需要规避障碍物的问题,设计一种将跟踪制导律与改进人工势场法相结 合的航迹规划算法。对人工势场法进行适应性改进,建立无人机动力学模型,阐述定距离跟踪制导律的设计方法, 并采取加权求和与运动学约束的方式将定距跟踪制导律与人工势场法二者结合。仿真实验结果表明：该策略具备有 效性和可行性。     

红外目标模拟器的光学设计

设计了一种用于红外光电系统性能测试的目标模拟器的光学系统。原理上采用一个无焦系统与后聚焦系统的组合系统,利用Zemax光学设计软件进行优化设计,最终设计结果为工作波段8~12μm,焦距230.599mm,视场12°,入瞳距600mm,入瞳直径100mm。整个光学系统有9个光学透镜,最大口径229.77 mm,光学系统达到衍射极限,全视场MTF均优于0.39,80%的能量集中在23μm的弥散圆内。各项指标都满足设计要求,能很好地应用于红外光电系统的性能测试。